Hirschsprung's disease or Hirschsprung disease (HD), . Both of these disorders are more common in Hirschsprung’s patients than in the general population. . Hirschsprung’s disease is a congenital disorder of the colon in which certain nerve cells, known as ganglion cells, are absent, causing chronic constipation.

Hirschsprung’s Disease What is Hirschsprung’s disease? Hirschsprung's disease is a disorder that occurs when ganglia (nerve cells . blockage occurs. As the blockage builds up, the colon enlarges; this is called congenital (present at birth) megacolon (enlarged colon). What causes Hirschsprung’s disease? Currently, the exact reason why children with Hirschsprung’s . http://my.clevelandclinic.org/disorders/hirschsprungs_disease/hic_hirschsprungs_diseas e.aspx MedlinePlus Medical .

Hirschsprung's disease and other congenital functional disorders of colon. Short description: . Congenital functional disorders of the colon; Congenital macrocolon, . Hirschsprung's disease; Hirschsprung's disease and allied congenital conditions; Hyperganglionosis; Idiopathic congenital megacolon; Lethal white syndrome of foals; Long segment Hirschsprung's disease; Macrocolon; Megacolon, congenital;

Hirschsprung's disease is sometimes linked to other inherited or congenital conditions, such as Down syndrome. Symptoms. Symptoms that may be present in newborns and infants include: Difficulty with bowel movements; . The abnormal section of colon must be taken out with surgery. Most commonly, the rectum and abnormal part of the colon are removed.

Hirschsprung's disease (HSCR) is characterized by the absence of particular nerve cells . Many other medical conditions can be associated with Down’s such as: congenital heart disease, leukemia, respiratory problems, eye and ear problems and Hirschsprung’s Disease. . The content of the website and databases of the National Organization for Rare Disorders (NORD) is copyrighted and may not be reproduced, copied, downloaded or disseminated, .

Hirschsprung's disease sometimes occurs in children with other disorders of the autonomic nervous system, such as congenital central hypoventilation syndrome, . remove the diseased portion of bowel, and perform a "pull-through" procedure, which repairs the colon by connecting functional bowel to the anus. The pull-through operation usually establishes fairly normal bowel function. . Hirschsprung's disease is a congenital abnormality that has no known means of prevention.

Congenital aganglionic megacolon (Hirschsprung disease) Author David E Wesson, MD. David E Wesson, MD. Professor of Surgery . et al. Conditional ablation of GFRalpha1 in postmigratory enteric neurons triggers unconventional neuronal death in the colon and causes a Hirschsprung's disease phenotype. Development 2007; 134:2171. Uesaka T . Spitz L, Tsuji H, Pierro A. Hirschsprung's disease: functional and psychological follow up comparing total colonic and rectosigmoid aganglionosis. Arch .

What Is Hirschsprung's Disease? Hirschsprung's disease is a rare congenital disorder that causes an obstruction (or blockage) of the intestine.

Hirschsprung Disease, Pediatric. Lusine Ambartsumyan . Basics. Description; Epidemiology; Risk Factors; Pathophysiology; Commonly Associated Conditions; Diagnosis. History; . (chronic infectious colitis of the colon) . Dasgupta R, Langer JC. Evaluation and management of persistent problems after surgery for Hirschsprung disease in a child. J Pediatr Gastroenterol Nutr.